The oral drug delivery has more attention among the different routes of drug administration. Regretfully, the variability of gastrointestinal physiology same as gastric emptying time, pH and agitation to cause an unpredictable bioavailability and lack of drug effectiveness. Prolongation of gastric time with sustained release systems leads to reduction the number of dosage regimen and improvement of drug bioavailability. Ranitidine is histamine H2 antagonist widely used in the treatment of gastric ulcer. It is suitable drug for gastroretentive floating granules due to its short half life and poor absorption in lower gastro intestinal tract. In the present research work, D-optimal design was used for optimization of levels of independent variables (sodium bicarbonate, beeswax, ethyl cellulose & citric acid) on dependent variables t50 and time taken for 100 % release in the formulations of ranitidine gastroretentive floating garnules with less experimentation. From the results it was concluded that sodium bicarbonate (10 %), beeswax (20 %) and ethyl cellulose (10 %) and citric acid (0 %) were favorable for formulation of gastroretentive floating granules employing vee gum as release retardant.
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